ABSTRACT
The objective of this paper is to clarify, whenever possible, the determinants in the emergence of biological agents to improve aspects connected with public health and biosecurity. Case study of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is investigated to assess the likely emergence from a wildlife spillover and/or scientific research in labs with unexpected accident. Using a meta-analysis, results suggest that a natural spillover of SARS-CoV-2 that has generated more than 5.2 million of deaths, in analogy with natural disaster, seems to have a remote probability, instead a lab accident in the process of scientific research has a probability of occurrence of about 15-30%. These results here are important to support decision making of policymakers for global biosecurity strategies with appropriate responses to prevent the future diffusion of vital agents similar to SARS-CoV-2 in environment and society.
ABSTRACT
New Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes the Coronavirus Disease 2019 (COVID-19), an infectious illness that has generated a pandemic crisis worldwide. One of the fundamental questions in science and society is how SARS-CoV-2 has been originated to design best practices directed to prevent and/or to cope with future hazardous pathogens. The study confronts this question here developing a meta-analysis, which endeavors to explain, whenever possible, unknown sources of the SARS-CoV-2. Findings suggest that the natural spillover of novel viral agents that generate more than 6.00 M deaths worldwide in about two years (such as, SARS-CoV-2 from February 2020 to March 2022) has a remote probability of occurrence (using an analogy with the probability of natural disasters generating a lot of fatalities), whereas science advances on hazardous viral agents and consequential lab accident have a (higher) probability of occurrence (about 13-20% like in manifold lab accidents). The findings of this meta-analysis suggest the vital role of improving the technical guidelines of biosafety at all levels in laboratories during the development of scientific research of experimental virology on hazardous pathogens to minimize risks of pandemic threats in environment and human society.